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ADHD Medications and Treatments

ADHD affects an estimated 3% to 5% of children and adults in the U.S. Dr. Richard Sogn shares information and advice about attention deficit hyperactivity disorder, including its causes, diagnosis, and promising ADHD treatments

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WebMD Health News

Monday, February 20, 2006

Are Stimulants Overprescribed or Misprescribed?
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It's often difficult to determine whether those claiming that stimulants are overprescribed are opposed to stimulant medications, disagree that ADHD even exists, or disagree with psychiatric treatment of any disorder.

Those opposed to psychiatry should say so. If they are against the prescription of any psychiatric medication, such as being against the use of antidepressants for post-partum depression, they would be opposed to the prescription of stimulants whether or not they were overprescribed. They shouldn't hide their agenda in an argument about the overprescription of stimulants and should argue their point.

Others disagree that ADHD exists and tend to blame problems on poor parenting, laziness, the school system or moral character. ADHD is one of the most studied childhood disorders as there have been hundreds of scientific studies with thousands of subjects. More recent studies involve the tools of modern day science, including metabolic studies, genetic studies, and brain imaging techniques.

The Human Genome Project found that ADHD is the most common genetic (inherited) childhood behavioral disorder. Those who disagree with the existence of ADHD should argue against the scientific evidence, rather than hide their agenda in an argument about the overprescription of medications.

Are stimulant medications overprescribed? Multiple scientific studies have found that only about 50% of those with ADHD are ever diagnosed and treated. One could then argue that medications are underprescribed, rather than overprescribed. This is an important question as untreated ADHD is related to impairments in many areas of life. Undiagnosed and untreated ADHD is related to lower school achievement, problems with interpersonal relationships (with peers, parents, and later spouse and children), a lower level of occupational achievement, a higher rate of motor vehicle accidents, a higher rate of alcohol and drug use, and a higher rate of social and emotional problems (low self-esteem, anger, frustration).

Untreated ADHD compromises the overall quality of life.

Rather than asking whether medications used to treat ADHD are overprescribed, a better question is whether they are misprescribed. Many children who are having difficulty paying attention in class are struggling with anxiety, depression, or learning disabilities, or are reacting to stress in their life and do not have ADHD. Many children with behavior problems are not struggling with ADHD but have symptoms of irritability related to a mood disorder (depression, bipolar disorder), a sleep disorder (sleep apnea from enlarged tonsils), a medical problem, or a behavioral disorder (Oppositional Defiant Disorder) without ADHD.

No parent and child should walk into the pediatrician's office with complaints of inattention or disruptive behavior and walk out 15 minutes later with a prescription in hand. A diagnosis should only be made after a comprehensive evaluation which documents significant impairment in academic, social, or occupational functioning in multiple settings and rules out other problems that might be causing the symptoms.

A diagnosis of ADHD should never be made on the presence of symptoms alone. Although everyone is occasionally sad, most are not severely or clinically depressed requiring treatment with antidepressants. Inattention, distractibility, hyperactivity, impulsivity, and problems with planning, organization, time management, follow through and forgetfulness must be frequent and of such intensity and duration as to cause significant problems in multiple areas of life functioning for a diagnosis of ADHD.

Medications for ADHD are misprescribed in the same way that antibiotics for viral infections are misprescribed. Rather than doing a thorough evaluation and laboratory testing to differentiate a viral infection from a bacterial infection for someone with flu-like symptoms, it's often easier just to write a prescription. Rather than doing a comprehensive evaluation of the child with difficulties paying attention or experiencing disruptive behavior, and then developing a comprehensive treatment plan that may or may not include medications, it's sometimes easier for physicians with little time, training, or experience in evaluating and treating ADHD to simply write a prescription.

The misprescribing of stimulants doesn't make stimulants "bad", anymore than antibiotics are "bad." However, it does indicate the tremendous need for an increased number of professionals highly trained in evaluating children, adolescents, and adults for ADHD and related difficulties.

Related Topics: New Numbers on ADHD in US Kids, WebMD Daily Video: Too Scared - Social Anxiety Disorder

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Posted by: Richard Sogn, MD at 3:16 AM

Friday, February 10, 2006

Cardiac Warnings For Stimulant Medications
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Following an FDA advisory panel's recommendation to place a warning regarding potential cardiovascular side effects on the label of stimulant medications used to treat ADHD, many parents have been concerned about safety of their children taking such medications.

Stimulant medications have been used for over 60 years to treat symptoms related to ADHD. Stimulants are one of the most extensively studied medications in children and adolescents, with over 200 well-controlled studies involving thousands of children and adolescents over the past 50 years.

An NIMH (National Institute of Mental Health) sponsored study, studied over 300 preschool children and over 300 school age children on methylphenidate (Ritalin) for 14 months, then followed them for an additional 4 years. The overall consensus from these studies has been that stimulants have been effective and relatively safe for over 60 years of use.

Currently, about 3,500,000 children and adolescents are being treated for AD/HD with stimulants as one part of their treatment plan. Over the past five years, there have been fewer than 20 sudden deaths reported on youth taking these medications, and it's unknown whether other factors, such as other medical conditions or other medications, played a role in these deaths.  It's extremely difficult to study or predict such rare, unexpected adverse events when their incidence is so extremely small compared to the numbers of children and adolescents taking medications.  Several large studies are underway to try to determine those small number of individuals who might be at risk.

As with many other medications, parents must weigh the significant risk of long-term impairment from untreated ADHD with the rare, unexpected, but potentially serious adverse events associated with stimulants. The evidence from over sixty years of clinical experience and hundreds of studies currently finds that these medications are safe for the majority of children and adolescents who take them. The use of stimulants in adults is much different, as they are often starting medications at an age when they might be developing high blood pressure and have other cardiovascular risk factors. I've addressed the use of stimulants and their associated risks in adults in a recent WebMD blog.

Note: In addition to information from research studies and clinical experience, much of the above information was adapted by recent statements from the American Academy of Child and Adolescent Psychiatry and Dr. Laurence Greenhill, who have pledged to work closely with the FDA to determine the prevalence of ADHD medication adverse events.

Dr. Richard Sogn

Related Topics: Reducing the Side Effects of ADHD Medications, ADHD Behavioral Therapy

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Posted by: Richard Sogn, MD at 4:39 PM

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