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Wednesday, November 15, 2006

Pre-school children and Ritalin (Part 2)
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In my last blog I discussed an important new study that looked at the use of methylphenidate ("Ritalin", etc.) in preschool age children.

The data were reassuring: although, compared to its use in older children, side effects occurred more often and it was effective in fewer kids, the majority of children appeared to benefit and only a minority (11%) stopped the medication due to significant side effects (which resolved when the medication was discontinued). Best of all, no really bad events occurred.

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But this study does not really answer the question "should we use stimulant medications in children this young?" - a topic some of you addressed in your comments and, as promised, the topic of today's blog.

This is an important and legitimate question. Few trends have provoked more heated controversy and passionate opinions than has the surge in the use of psychiatric medications in children, and especially in those who are less than 6 years old.

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Dr. P's view
As a developmental pediatrician getting long in the tooth, I have prescribed stimulant medications to lots of children. While I have seen their clear benefit, I too wonder and worry if starting such a medication in a young child whose brain is still actively shaping itself could have a long term effect - bad or good - on the final architecture and chemistry of that brain. Since this phenomenon is relatively recent, we simply don't know if this could happen and, frankly, we are unlikely to for another decade or two, when these kids grow up and are studied.

Given this unresolved concern, why then do I continue to prescribe stimulant medications to young children? It has evolved out of my clinical work.

I had been trained not to use medications (this, of course, when dinosaurs roamed the earth). It took me many years and many failures of recommending improved limit-setting and time-out and other environmental interventions which seemed to have no effect before I finally screwed up my courage and prescribed a stimulant for ADHD.

Kids with ADHD who need and benefit from medications are those who had been having serious problems in their lives: abysmal school performance, no friends, disrupted family relationships, poor self-esteem...the list is always long and heartbreaking. And I saw stimulant medications in many cases providing benefits that were so far superior to what I had been previously recommending, so gratifying for the child and parents, that it seemed like malpractice not to offer the child and family this way to relieve the child's suffering.

So, despite the unknown potential for long term side effects, the short term benefits are so undeniable and the side effects, when they occur, so manageable, that I recommend these medications without apology.

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But, of course, some beg to differ. I have followed the objections to using stimulants for ADHD with interest. Generally they boil down to the following:

  • It's a conspiracy by psychiatry and other nefarious elements (I suppose like me) to control and shape the minds of children, and/or it's an abominable practice fostered by unscrupulous physicians on the payroll of the drug companies. This is a time-honored ad hominen objection: if you have no coherent argument or evidence on your side, criticize the motives and honesty of the clinicians.
  • It somehow just doesn't sit right. The implicit prejudice is that behavior problems must be managed by environmental engineering, not by tinkering with brain chemistry (even if it's clear that a difference in brain chemistry and not an inappropriate environment causes ADHD in most kids).
  • These meds are a crutch, used by lazy, ineffective parents (and professionals) who want to chemically restrain their normal, active kids. In fact, they often argue, ADHD doesn't even really exist.

(Of the three, I find this last the most egregious. It unfairly damns parents of kids with ADHD as the cause of the problem, as maliciously using medications for their own selfish interests and not to benefit their child, and as not knowing or caring what is best for their kid. Aside from the fact that I've never met such a parent, it is a boneheaded and mean-spirited trifecta: self-righteous insensitivity to the real suffering experienced by kids with ADHD; the unconscionable accusation that parents are lazy and selfish and incompetent (with the self-righteous implication that "if I were this child's parent I would cure it beautifully without the need for medications. Why can't you?" This inevitably comes from someone who never raised a child with ADHD themselves.); and a stunning lack of insight into the complicated forces of both nature and nurture that guide human development and behavior.

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OK, that's my rant and I'm sticking to it. What about the use of stimulants in pre-school kids? Here's my take:

  • By age 4 - but not before - good clinicians can be reasonably accurate in making a diagnosis of ADHD. If a child is experiencing signficant problems in the important aspects of his life (learning, relationships, self-esteem, etc.) then medications can be incredibly helpful - just as they often are in older kids - and should be considered.
  • The diagnosis of ADHD can't really be made (although sometimes suspected) in two-year-olds. Let's face it, all two-year-olds have ADHD (and a touch of psychosis while we're at it). Stimulant medications at this age are a no-no.
  • The same goes for three-year-olds. Although, occasionally a child is in such trouble (e.g., the child I saw who was being expelled from his 3rd child care site, who had all the hallmarks of ADHD, and whose mom was going to have to leave her much-needed job to care for him) that, in desperation, I have tried stimulants - with variable success.

Bottom line: If you are parent of a child 4 years or older whom you and the professionals are convinced really has ADHD and who is having a real hard time in his life, don't be afraid to engage in a 'therapeutic trial' of stimulant medications. Trust yourself. You'll know if it is helping your child or not. You'll recognize side effects that might warrant discontinuation. You'll know if the stimulants are a boon or bust for your child. Don't let the self-serving, self-righteous sneeries make you feel like a bad parent for doing so.


Related Topics: ADHD: An Update on Diagnosis and Treatment for Kids, ADHD: Boys Vs Girls

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Posted by: Dr. Parker at 11/15/2006 05:22:00 PM

Wednesday, November 01, 2006

Pre-school children and Ritalin: Boon or Bust?
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There is an ongoing, important, and quite passionate debate about using medications in young children to improve their behavior or mood.

There are usually two aspects to the controversy:
- Is it safe and effective to use them?
- And even if it is, should we do so anyway?

In this blog I'll discuss the first question, which this new study addresses. In my next blog, I'll discuss the "should" question.

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This new study is by far the largest and the best to examine the safety and side effects of using methylphenidate (trade names such as Ritalin, Concerta, Metadate) for the treatment of ADHD in preschool children, ages 3-5 years.

The study

  • 183 children with a diagnosis of ADHD participated over the course of a year.
  • This was the best kind of study: a prospective study lasting almost a year with side effects ("adverse events") compiled by investigators who did not know the child's medication history.

What the study found

  • 70% of the children experienced no significant side effects to methylphenidate.
  • 30% reported moderate to severe side effects.
  • 11% discontinued the medication due to unacceptable side effects. The most common reasons were emotional outbursts and irritability.
  • The following side effects were reported (which tended to diminish over the course of the year): Crabby/irritable (44% initially dropping to 24% after 10 months); Prone to crying (37% dropping to 27%); Tearful/sad/depressed (24% dropping to 9%); Listless/tired (12% dropping to 3%).
  • Other side effects remained relatively constant over the year: Appetite loss (42%); Skin picking (37%); Trouble sleeping (29%); Worried/anxious (28%); Social withdrawal (17%); Headaches (3%).

The authors conclude:

  • There are more side effects when using methyphenidate in preschool children, compared to school age children. 11% discontinued the medication due to side effects, compared to about 1% in school-age kids.
  • The side effects in preschool children tended to differ from school age children, with more emotional outbursts, irritability, sleep problems and repetitive behaviors.

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So them's the facts.

This is an extremely useful study for clinicians. It tells us that side effects of methylphenidate are more common and somewhat different in preschoolers, compared to school-age kids. It cautions us to watch carefully for emotional outbursts, for crabbiness, for repetitive type behaviors.

And, of course, everyone agrees that any worrisome side effects should prompt a discontinuation of the medication, after which the side effects inevitably go away. Additionally, we can anticipate that 2/3 of young kids will experience no significant side effects over a year.

Are you horrified or relieved by this study? The answer, I suspect, has more to do with your pre-existing opinion about the use of ADHD meds than it does with the actual statistics: is the glass 2/3 full or 1/3 empty? Or should there not even be a glass for pre-school children?

Here's my question to you: What about the 4 year old who has ADHD and whose life is a misery? Should I recommend using methylphenidate to treat his ADHD? What about in a 3 year old? A 2 year old? These are questions I agonize about regularly in my development and behavior clinic.

Which will be the topic of my next blog. In the meantime, let me know what you think.

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*Article cited:
"Safety and tolerability of methylphenidate in preschool children with ADHD."
Wigal T, et al. Journal of the American Academy of Child and Adolescent Psychiatry. November, 2006.



Related Topics: FDA Okays Treatment Patch for Kids, Choosing the Right ADHD Medication for Your Child

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Posted by: Dr. Parker at 11/01/2006 03:37:00 PM

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