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    Do Statins Impair Memory?

    A few weeks ago, FDA announced that cholesterol-lowering drugs known as statins would have to carry warnings that side effects can include, among other things, possible memory loss. The news appeared in many papers and on news channels. Unfortunately, FDA’s complete statement regarding statins and memory loss was not revealed to the public.

    It seems hardly a day goes by that I don’t wake up and see some negative press regarding statins. On various news channels, I once again heard that some “expert” said that statins make people lose their memory. It would be nice to hear that statins have changed the face of cardiovascular disease by reducing morbidity and mortality dramatically — 40-50%. Despite this, we still have a long way to go to eradicate cardiovascular disease, which still remains the number 1 killer of men and women in the United States.

    I have been busy seeing patients, but I felt I needed to take the time to address the new comments. Back in 2006, the Statin Safety Task Force of the National Lipid Association formed a Neurology Panel and examined the evidence-based literature, a 22 million-person HMO database, and the FDA adverse event reporting system to assess the effects of statins on the nervous system. This was an independent body of experts that included the top thought leaders in the world in their specific field of expertise.

    They asked some fundamental questions, including whether or not statins impair cognition and memory. Their conclusion, drawn from controlled studies and meta-analyses of cohort studies, was no. First of all, there is no evidence that statins are a common or significant cause of cognitive decline or memory loss. This is supported by large, randomized clinical trials, including the Heart Protection Study (HPS) and the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER). The HPS was a large statin trial and included 20,536 participants who were followed over a 5-year period. Also, the Jupiter Study, which involved approximately 18,000 patients on Crestor 20mg, had absolutely no data to suggest that a statin has any effect on the neurologic system, including loss of memory.

    I would never say that a medicine of any kind does not cause some type of problem in a patient. It is true that probably any medicine can cause any symptom in any patient. I like to think of this as a kind of allergy called an idiosyncratic reaction. It is always possible that a rare case of impaired memory or cognition could occur, but this would most likely represent an idiosyncratic reaction. There is no evidence of a causal relation between impaired memory and/or cognitive dysfunction. In fact, statins may actually benefit some patients’ memories: A paper published last year in the journal Experimental Neurology, which is one of the premier journals focusing on neuroscience, stated that there is evidence statins may have a beneficial effect on the progression of Alzheimer’s disease.

    This information was not part of the general news coverage of FDA’s decision, even though FDA’s communication further reports, “Data from the observational studies and clinical trials did not suggest that cognitive changes associated with statin use are common or lead to clinically significant cognitive decline.” Similarly, the 2006 NLA expert paper on statin safety addressed raised anxieties on the potential reports regarding cognition, but investigators were unable to conclusively establish the clinical relevance or pathologic mechanism of these outcomes.

    I think the best way to approach a patient with peripheral neuropathy or impaired cognition while on statins is to first recommend a thorough exam by a neurologist in an attempt to find a cause. If this is not possible, it is certainly appropriate to stop the statin to see what happens. Due to the length of time it can take to resolve reversible peripheral neuropathy, the patient should remain off the statin for 6 months. Patients with impaired cognition should wait about 3 months. If symptoms improve then it is certainly possible that the statin the patient was taking was causing or contributing to the memory loss. One might want to consider switching to a different statin, as the benefits of statins in reducing cardiovascular morbidity and mortality have been proven. If the neurologic symptoms do not improve, the problem may be categorized as unrelated to the statin and one should restart therapy based on a risk-benefit analysis. One must remember that there are many reasons a patient taking statins may experience impaired cognition and/or peripheral neuropathy, including vascular disease, diabetes mellitus, and advancing age. Before stopping any statin altogether, it’s important to exhaust every possibility.

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