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    Xeomin: A New Competitor for Botox and Dysport

    By Robert Kotler, MD, FACS

    Some time ago, I discussed and compared Botox® Cosmetic and Dysport®.  Recently, a new and chemically distinct product, known as Xeomin, joined the wrinkle-filler lineup.

    Xeomin has been FDA approved specifically for the vertical frown lines between the eyebrows.  Apparently, this product was previously approved for use in adults with cervical dystonia, a condition in which spasm and contractions of the neck muscles produce a very uncomfortable and unsightly appearance.  Likewise, it had been approved for blepharospasm, which is involuntary flickering of the orbicularis muscle which surrounds the eye.

    To give you the most authoritative information, I am now going to quote from a review article written by Yael Halaas, MD:

    “Xeomin is manufactured by Merz Pharmaceuticals and has been used by more than 84,000 people worldwide.  It is now approved for use in 20 countries.

    Like other drugs in this category, Xeomin works by paralyzing wrinkles.  It blocks the signals from the nerves to the muscles.  As a result, the targeted muscle cannot contract.

    Xeomin versus Botox and Dysport

    Botox, Dysport, and Xeomin have a lot in common, but they also have some important differences.  Unlike its predecessors, Xeomin does not need to be refrigerated.  This may be an advantage when it comes to distribution.  What’s more, Xeomin is “naked.”  There are no additives – just botulinum toxin type A.  This may lessen a patient’s likelihood of developing antibodies to Xeomin.  When your body senses a foreign invader, it responds by creating antibodies and launching an attack.  If this were to occur with a neurotoxin such as botulinum toxin type A, it may not have its desired effects.

    Xeomin is said to be more like Botox than Dysport.  It takes about one week for the full effects of Xeomin injections to be realized, and once this occurs, the results last from 3-6 months.  Dysport, Xeomin, and Botox should not be used interchangeably.  They should also only be administered by skilled injectors, such as board-certified facial plastic surgeons in sterile environments, such as medi-spas or doctors’ offices.  Xeomin should not be injected in beauty salons, malls, or at Xeomin parties in the home.”

    I am pleased to know there are additional products that can be added to the palette of dermatologists and cosmetic surgeons to help neutralize facial wrinkles.

    Always discuss with your doctor the pros and cons of each particular product.  I can tell you, however, that so far, the Botox Cosmetic and Dysport class of drugs have been very safe and very successful.

    The popularity of these temporary muscle-paralyzing injections is deserved.


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